VeloJect: Behind Our Clinical & Business Pursuit
- Post-op pain management is a top patient concern and a tremendous problem for HCPs.
- Adoption rates of intraop pain control hinges on improved efficacy & administration technique.
- The VeloJect concept aims to deliver control, ease of use, and precision in a clinically optimized manner.
The rapid shift of hip & knee replacement to the outpatient setting (ASC) has made post-operative pain management one of the most important determining factors for clinical success and patient satisfaction.
Yet, there is no accepted or agreed “cocktail” of medication that should be injected, nor an agreed site within the surgical field where pain-management injection(s) should occur
Pacira Pharamceuticals’ Exparel® (liposomal bound bupivacaine) holds tremendous potential for long acting pain relief in hip & knee replacement, but inconsistent clinical efficacy puts a hard ceiling on adoption.
Repetitive injection of anesthetic into tissues of varying resistance is time consuming, imprecise, and physically taxing on a surgeon’s hands – especially with the use of a smaller gauge needle. Larger gauge needles allow fluid egress, thus making the injection futile.
Uneven delivery of a drug or drug cocktail holding great promise for prolonged pain control was the catalyst for VeloJect’s patented and patent-pending innovations.
Past & Present State of the Art Technology
- The manual process of depressing a plunger to advance a fluid solution through a narrow trocar has remained virtually unchanged in 160 years.
- The standard legacy design is adequate for many non-surgical purposes, but is undesirable and clinically disadvantageous for contemporary use in a modern operating theater.
- Orthopedic surgery, colorectal surgery, spinal surgery and other complex procedures require a more precise & controlled administration of compound solutions for pain control and other purposes.
The Pharmaceuticals Work But the Delivery Method?
- Reliably and reproducibly administering fluid at a dose-appropriate level with a thumb-actuated plunger is virtually impossible.
- Mismatch between larger volume/diameter syringes and smaller gauge needles leads to increased pressure that must be applied to expel fluid.
- Surgeons regularly concoct their own surgical technique and pharmacological compounds in an effort to overcome the inherent limitations of a manual needle and plunger.
- Inappropriate dosing and pharmacological dispersion in tissue is exceedingly common and has been known to cause clinical problems with pain control and other factors associated with recovery.
- Surgeon impatience, fine-motor muscle fatigue, time pressure to vacate the operating theater, and lack of any alternative clinical tools have made this essentially an unsolvable problem.
Pain Management: Opinions, Friction & Uncertainties Abound
- Skepticism among HCPs and hospital buyers persists around the clinical efficacy and reproducibility of Exparel®
- Selected community observations suggest that ~60% of the time, Exparel® works approximately 36 hours.
- Surgeons often rely on a larger 20-gauge needle due to time constraints and physical fatigue concerns.
- Many physicians accept the clinical uncertainties because pain control is so important for their patients and their paying institutions.
- But many more do not.